Monoclonal Antibody Screening and Production

Monoclonal antibodies (mAbs) stem from a single, unique parent cell. As a result, these antibodies only bind to a single epitope. The production of monoclonal antibodies is crucial to research and treatment efforts regarding various diseases, both infectious and non-infectious. At Cell Culture Company, we provide customized production of monoclonal antibodies. Our team has manufactured hundreds of client monoclonal antibodies over our 40 years in business. We have the know-how and capability to carry out mass-scale antibody production.

Monoclonal Antibody Screening

The discovery process connected with monoclonal antibodies refers to the screening and identification of certain antibodies that pinpoint a specific epitope (part of an antigen molecule) for the diagnosis and treatment of various ailments – a recent example being COVID-19.

Monoclonal Antibody Production

The treatment of cancer has been enhanced recently by the design and production of monoclonal antibodies. The monoclonal antibodies we produce at Cell Culture Company have been utilized as reagents for diagnostics, research, and the development of products.

The production of custom monoclonal antibodies is a technical, time-consuming, and demanding task. Customers may give our team their antibody-producing hybridoma or other cell lines. Our scientists are able to provide monoclonal antibodies customized to the specifications of the customer.

The generation of monoclonal antibodies often involves the immunization of mice, generating hybridoma, clone screening, and ramping up the production of clones. At Cell Culture Company, we offer an alternative process using perfusion-based bioreactors to produce monoclonal antibodies that are easy-to-scale.

The process begins with inoculating a single-use hollow fiber cartridge by which a continual flow of media transports nutrients throughout the semi-permeable fibers. For the purposes of antibody production, the bioreactor environment referred to here is monitored and sustained at ideal conditions. The bioreactor is responsible for a concentrated and continual stream of harvested product over a period of several weeks to months.

At Cell Culture Company, we offer an array of services, including downstream processing and purification of monoclonal antibodies. To learn about our specialized process for the production of antibodies, give us a call today at 763.786.0302 or reach us through our contact form.