Proteomics is the study of proteins on a large scale and involves the identification and quantification of proteins present in an organism, tissue or cell at a given time. As a group, this is called the proteome. Studying the proteome provides insight on protein composition, structure and activity.
Proteomics has become increasingly important for the study of functional genomics and disease models. Various methodologies are used including sequencing, mass spectrometry and immunoassays. As part of this research, post-translational modifications are identified.
Translation from mRNA can not only cause differences in protein expression, but many proteins are also exposed to an extensive variety of chemical modifications after this translation and many of these post-translational modifications are critical to the protein’s function. While the most commonly studied post-translational modifications are phosphorylation and glycosylation, other modifications include ubiquitination, methylation, acetylation, glycosylation, oxidation, and nitrosylation.
Contact Cell Culture Company to discuss how we can support your proteomic research.