Purification and Downstream Processing Services

Purification for Diverse Proteins:

• Protein Types: Purify monoclonal antibodies (IgG, IgM), antibody fragments (Fab, F(ab)2, scFv, BiTE, sdAb, Bispecific), recombinant proteins (Fc-Fusion, His-tagged, FLAG-tagged, GST-tagged, MBP-tagged, etc.), and more.
• Chromatography: Employ your preferred protocol including affinity chromatography (Protein A/G/L, CaptureSelect, IMAC, Glutathione), mixed-mode chromatography (Capto™ adhere/MMC, CHT), ion exchange, hydrophobic interaction, and size exclusion tailored to your specific biomolecule and desired purity.
• Technical Services: Leverage our team for technology transfer, process development, non-GMP (RUO/Pre-Clinical) manufacturing, process evaluation and validation, and GMP manufacturing support.
• Scale: Process development and purification from analytical to preparative scale, handling microgram to multi-gram quantities.

Streamlined Processing:

• Clarification: Remove cell debris and large impurities using centrifugation, microfiltration, or other techniques.
• Polishing: Achieve high-purity final product through advanced chromatography or other polishing steps.
• Viral Inactivation and Filtration: Ensure product safety and regulatory compliance with dedicated viral inactivation and filtration processes through our partners.
• Ultrafiltration/Diafiltration: Concentrate and exchange buffers for downstream applications.
• Sterile Filtration: Guarantee product sterility for final formulation and administration.
• Formulation: Develop and optimize formulations for stability, long-term storage, and desired delivery route.

FAQs:

What purification technologies do you use?

We employ a vast array of technologies including chromatography, filtration, centrifugation, and more depending on your specific biomolecule and desired purity.

Can you handle large-scale purification projects?

Absolutely! Our scalable processes ensure consistent quality and regulatory compliance for large-scale production.

What are the costs associated with your services?

Costs depend on the complexity of your biomolecule, desired purity level, and scale of production. However, we offer flexible pricing options to meet your budget needs.

Do you offer analytical services along with purification?

Yes, we offer comprehensive analytical services to assess purity, activity, and stability of your purified product, ensuring quality control throughout the process.