Downstream Services

Purification and Downstream Processing Services

At C3, we have the capability and expertise to perform purification and downstream processing for your antibody or recombinant protein product. C3 can execute your existing purification process, or work with you to develop a robust purification process for your protein.

Technical Services and Support

Technology Transfer
Process Development
Non-GMP (RUO/Pre-Clinical) Manufacturing
Process Evaluation and Validation
GMP Clinical and Commercial Manufacturing

Scale 

Analytical to preparative column chromatography
Microgram to multi-gram quantities

Protein Types 

Antibodies
– Various Species of IgG and IgM
Antibody Fragments and Derivatives
– Fab, F(ab)2, scFV, BiTE, sdAb, Bispecific Antibodies
Recombinant Proteins
– Fc-Fusion Proteins, Tagged Proteins (His, FLAG, GST, MBP, etc.)

Chromatography

Affinity
– Protein A/G/L, CaptureSelect, IMAC, Glutathione, etc.
Mixed-mode
– Capto™ adhere/MMC, CHT, etc.
Ion Exchange
Hydrophobic Interaction
Size Exclusion

Processing

Clarification
Polishing
Viral Inactivation and Filtration
Ultrafiltration/Diafiltration
Sterile Filtration
Formulation

Outsourcing Support

Viral Clearance Studies
Impurity Analysis
Formulation Studies
Large Batch Final Fill

Additional Services

Deglycosylation
Endotoxin Removal
Conjugation/Labeling
Enzymatic Cleavage