Upstream Services

C3 is committed to quality, expertise and service. We bring the knowledge and skill that comes with expanding more than 2,650 different cell lines for 1700+ organizations, delivering monoclonal antibodies, recombinant proteins, viruses, whole cells and cellular extracts from mammalian and insect cell production platforms. 

Our team understands the need for robust, predictable processes that support scale up for GMP manufacturing. This requires flexibility in how we apply technology. We utilize our proprietary perfusion bioreactors along with traditional cell culture methods for both adherent and suspension cells. 

C3’s perfusion bioreactors employ hollow fiber cartridges that reduce production risks. This cell culture technology supports cell densities at 1E9 cells/mL, achieving in vivo-like conditions, which enhance cell-to-cell contact and communication. Results include improved cell health and greater yields, especially for low-expressing cells that struggle in tanks. 

C3’s Custom Upstream Cell Culture Services include:

  • Process Development
  • MCB/MWCB Generation and Characterization
  • Custom Large-Scale Production of Whole Cells and Conditioned Media
  • cGMP and R&D Production of Monoclonal Antibodies and Recombinant Proteins
  • Dedicated Project Management for your protein (Life Sciences PhD- and MA-level)